Dextra 糖化学专家
Dextra Laboratories Ltd
Dextra实验室成立于1989年，致力于为科学研究界提供碳水化合物合成和分析服务，是碳水化合物化学方面的专家，为研发提供碳水化合物分子目录，并为复杂碳水化合物的临床开发提供CDMO服务。Dextra为具有挑战性的复杂碳水化合物的全合成提供世界领先的创新解决方案，通常简化路线，减少实现目标化合物所需的合成步骤数量。从几毫克到多公斤，我们的化学家在低聚糖和手性化学方面提供无与伦比的专业知识，使您的项目从发现到临床试验。
Dextra为碳水化合物和其他复杂分子的合成提供了创新的合成解决方案，通常减少了获得目标化合物所需的合成步骤，我们提供专业管理的项目，由我们的高素质和经验丰富的化学家承担。我们的目录展示了碳水化合物产品的全面范围，开发糖生物学的复杂性和多样性。产品包括新糖蛋白，新糖脂，肝素衍生物，亚氨基糖，血型产品，低聚糖，聚糖，砌块和一系列糖生物学和可用于标准物质的稀有糖类。
我们对产品和工艺开发的综合方法使我们能够在需要的地方无缝过渡到大规模和GMP批次，我们的核心竞争力包括复杂寡糖化学，路线设计，工艺开发，优化和扩大，工艺验证，技术转让和GMP生产一期和二期临床试验。
我们设备齐全的分析实验室提供全方位分析技术的专家支持。所有的工艺都得到了强有力的质量管理体系和健康安全框架的充分支持，我们成功地通过了ISO9001:2015认证。
Dextra目前是ICE制药集团的重要组成部分，ICE制药在胆汁酸产品和药物用途领域处于领先地位。ICE Pharma成立于60多年前，现在是胆汁相关产品的全球主要参与者之一，在欧洲、亚洲、大洋洲、北美和南美拥有专业设施和子公司网络，得益于Dextra的长期经验，集团在碳水化合物的合成、分析和生产方面拥有领先的专业知识和全面的服务。
We offer a comprehensive custom synthesis service to take your project from discovery to clinical trial
Dextra provide innovative synthetic solutions to the synthesis of carbohydrates and other complex molecules, frequently reducing the number of synthetic steps required to access the target compound. We offer expertly managed projects undertaken by our highly qualified and experienced chemists. Our integrated approach to product and process development enables seamless progression to large scale and GMP batches where required.
Our core competencies include complex oligosaccharide chemistry, route design, process development, optimisation and scale-up, process validation, technology transfer and GMP manufacture for Phase 1 and Phase 2 clinical trials.
Our fully equipped analytical laboratories offer expert support with a comprehensive range of analytical techniques available. All activities are fully supported by a strong Quality Management System and Health & Safety Framework and we have successfully achieved ISO9001:2015 registration.
糖化学产品目录
BA51 D-Arabino-1,4-lactone
BA52 L-5-Deoxy-arabino-1,4-lactone
BA53 D-Fucose
BA54 L-Arabinose
BA55 D-Arabitol
BA56 L-Arabino-1,4-lactone
BA57 D-Arabinose
BA61 D-Allose
BA62 L-Allose
BA63 D-Altrose
BA64 L-Altrose
BA65 3,4-O-Isopropylidene-β-D-arabinopyranose
BA66 1,2:3,4-Di-O-isopropylidene-β-D-arabinopyranose
BA67 3,4-O-Isopropylidene-β-L-arabinopyranose
BA68 1,2:3,4-Di-O-isopropylidene-β-L-arabinopyranose
BA69 2,3:4,5-Di-O-isopropylidene-D-arabinose
BC114 D-α-Heptaacetobromocellobiose
BC115 D-β-Heptaacetocellobiosyl azide
BC116 D-β-Octaacetocellobiose
BC117 2-Nitrophenyl β-D-cellobioside
BC118 4-Nitrophenyl β-D-cellobioside
BC121 D-Cellobiose
BC122 D-Cellobial
BC123 D-Cellobial hexaacetate
BC221 Methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
BC303 Cellotriose
BC403 Cellotetraose
BC404 1,4-β-D-Cellopentaose
BD001 1,3,5-Tri-O-benzoyl-2-deoxy-2-fluoro-a-L-arabinofuranose
BD002 1,3,5-Tri-O-benzoyl-2-deoxy-2-bromo-a-L-arabinofuranose
BD003 2-Amino-b-L-arabinofurano-[1,2:4,5]-oxazoline
BD004 Methyl 2,3,6-tri-O-benzoyl-a-D-galactopyranose
BD005 Methyl 3-O-benzyl-a-D-galactopyranose
BD006 Methyl 4,6-dideoxy-4,6-dichloro-a-D-galactopyranose
BD007 6-O-p-Toluenesulfonyl-a-D-glucopyranose
BD008 Methyl 6-O-p-toluenesulfonyl-a-D-glucopyranose
BD009 Methyl 2,6-bis-O-p-toluenesulfonyl-a-D-glucopyranose
BG61 L-Glucose
BG62 L-Galactose
BG63 D-Gulose
BG64 L-Gulose
BG65 D-Galactosamine HCl
BG66 D-Galactose
BG82 N-Acetylgalactosamine
BG83 N-Acetyl D-Glucosamine
BG150 3-Deoxy-3-fluoro-D-glucose
BG151 4-Deoxy-4-fluoro-D-glucose
BG152 6-Deoxy-6-fluoro-D-glucose
BG153 2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl fluoride
BG154 3-Deoxy-3-fluoro-1,2:5,6-di-O-isopropylidene-D-glucofuranose
BG155 Methyl 4-deoxy-4-fluoro-α-D-glucose
BG156 2-Deoxy-2-fluoro-D-galactose
BG157 4-Deoxy-4-fluoro-D-galactose
BG158 6-Deoxy-6-fluoro-D-galactose
BG159 2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl fluoride
BG160 2-Azido-3,4,6-tri-O-benzyl-D-galactopyranosyl fluoride
BG161 Methyl 2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
BG162 Methyl 4,6-O-benzylidene-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
BG163 Methyl 3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
BG164 Methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
BG168 Methyl 3-O-benzyl-4,6-O-benzylidene-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
BG169 3-O-Benzyl-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose
BG171 3-O-Benzyl-1,2-O-isopropylidene-α-D-glucofuranose
BG173 p-Tolyl-3-O-benzyl-4,6-O-p-methoxybenzylidene-1-thio-α-L-idopyranose
BG174 p-Tolyl-2-O-acetyl-3-O-benzyl-4,6-O-p-methoxybenzylidene-1-thio-α-L-idopyranose
BH51 D-Hammelose
BH52 (S)-(-)-Hydroxymethyl-3(2H)-furanone
BL51 D-Lyxono-1,4-lactone
BL52 D-5-Deoxy-Lyxono-1,4-lactone
BL53 L-5-Deoxy-Lyxono-1,4-lactone
BL54 D-Lyxose
BL55 L-Lyxose
BL56 L-Lyxono-1,4-lactone
BL57 2,3-O-Isopropylidene-L-lyxono-1,4-lactone
BL58 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-L-lyxono-1,4-lactone
BL59 3,5-O-Benzylidene-L-lyxono-1,4-lactone
BL60 3,5-O-Isopropylidene-L-lyxono-1,4-lactone
BL61 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-L-lyxofuranose
BL62 3,5-O-Isopropylidene-D-lyxono-1,4-lactone
BL63 2,3-O-Isopropylidene-D-lyxono-1,4-lactone
BL64 3,5-O-Benzylidene-D-lyxono-1,4-lactone
BL65 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-lyxofuranose
BL66 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-lyxono-1,4-lactone
BM61 D-Mannose
BM62 L-Mannose
BM63 L-Mannitol
BM66 D-Mannosamine HCl
BM84 N-Acetylmannosamine
BM85 2,3:5,6-Di-O-isopropylidene-α-D-mannofuranose
BM86 2,3:5,6-Di-O-isopropylidene-α-L-mannofuranose
BM101 2-Deoxy-2-fluoro-D-mannose
BR51 D-Ribono-1,4-lactone
BR52 2-Deoxy-L-Ribose
BR53 L-Ribose
BR54 L-Ribono-1,4-lactone
BR55 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-L-ribono-1,4-lactone
BR56 2-C-Methyl-L-ribono-1,4-lactone
BR57 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-2-C-methyl-L-ribono-1,4-lactone
BR58 2,3-O-Isopropylidene-L-ribono-1,4-lactone
BR59 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-L-ribofuranose
BR60 2,3-O-Isopropylidene-2-C-methyl-L-ribono-1,4-lactone
BR61 L-Rhamnose
BR63 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone
BR64 2-C-Methyl-D-ribono-1,4-lactone
BR65 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-2-C-methyl-D-ribono-1,4-lactone
BR66 2-C-Methyl-D-ribose
BR67 2,3-O-Isopropylidene-D-ribono-1,4-lactone
BR68 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribofuranose
BR69 2,3-O-Isopropylidene-2-C-methyl-D-ribono-1,4-lactone
BR70 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-2-C-methyl-D-ribofuranose
BR71 2-C-Methyl-L-ribose
BR72 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-2-C-methyl-L-ribofuranose
BR81 2,3-O-Isopropylidene-D-ribofuranose
BR82 2,3-O-Isopropylidene-L-ribofuranose
BS101 2-Phenylethyl-β-D-thiogalactoside
BS102 2-Phenylethyl-β-D-thioglucoside
BS104 Isopropyl-β-D-thiogalactopyranoside
BS201 2-Thio-2-deoxy-D-glucose
BS501 5-Thio-D-glucose
BT41 D-Threono-1,4-lactone
BT42 L-Threono-1,4-lactone
BT43 D-Threose
BT44 L-Threose
BT61 D-Talose
BT62 L-Talose
BX51 D-Xylono-1,4-lactone
BX52 L-Xylose
BX53 D-Xylose
BX54 1,2:3,5-Di-O-isopropylidene-a-D-xylofuranose
BX55 1,2:3,5-Di-O-isopropylidene-a-L-xylofuranose
BX56 3,5-O-Isopropylidene-α-D-xylofuranose
BX57 1,2-O-Isopropylidene-α-D-xylofuranose
BX58 1,2-O-Isopropylidene-α-L-xylofuranose
BX59 3,5-O-Isopropylidene-α-L-xylofuranose
C214 Chitobiose octaacetate
C314 Chitotriose undecaacetate
C0720 Asialo, agalacto, biantennary (NGA2)
C0820 Asialo, agalacto, triantennary N-Glycan (NGA3)
C0860 Asialo, agalacto,biantennary fucosylated (NGA2F)
C0870 Monogalactosylated asialo, biantennary (G-NGA2)
C0920 Asialo, galactosylated, biantennary (NA2)
C0940 Asialo, agalacto, tetraantennary (NGA4)
C0960 Asialo, agalacto, bisected triantennary (NGA3B)
C1002 Neocarrabiose-4-O-sulfate sodium salt
C1003 Neocarratetraose-41, 43-di-O-sulfate sodium salt
C1004 Neocarratetraose-41-O-sulfate sodium salt
C1006 Neocarrahexaose-24,41,3,5-tetra-O-sulfate sodium salt
C1010 Neocarrahexaose-41,3,5-tri-O-sulfate sodium salt
C1011 Neocarraoctaose-41,3,5,7-tetra-O-sulfate sodium salt
C1012 Neocarradecaose-41,3,5,7,9-penta-O-sulfate sodium salt
C1015 Neocarrahexadecaose-41,3,5,7,9,11,13,15-octa-O-sulfate sodium salt
C1025 Asialo, galactosylated, fucosylated, biantennary (G1F)
C1026 Asialo galactosylated, fucosylated, biantennary (NA2F)
C1124 Asialo, galactosylated, triantennary (NA3)
C1170 Asialo, galactosylated, fucosylated, bisected, biantennary (NA2FB)
C1224 Asialo, galactosylated, tetraantennary, N-linked glycan (NA4)
C3201 Chondroitin disaccharide Δdi-0S
C3202 Chondroitin disaccharide Δdi-4S
C3203 Chondroitin disaccharide Δdi-6S
C3204 Chondroitin disaccharide Δdi-disE
C3205 Chondroitin disaccharide Δdi-disB
C3206 Chondroitin disaccharide Δdi-disD
C3207 Chondroitin disaccharide Δdi-triS
C3208 Chondroitin disaccharide Δdi-UA2S
C3209 Hyaluronic acid disaccharide ΔDiHA
C8002 N, N’ Diacetyl chitobiose
C8003 N, N’, N” Triacetyl chitotriose
C8004 N, N’, N”, N”’ Tetraacetyl chitotetraose
C8005 N, N’, N”, N”’, N”” Pentaacetyl chitopentaose
C8006 N, N’, N”, N”’, N””, N””’ Hexaacetyl chitohexaose
C8007 N, N’, N”, N”’, N””, N””’, N””” Heptaacetyl chitoheptaose
C8008 N, N’, N”, N”’, N””, N””’, N”””, N”””’ Octaacetyl chitooctaose
G0001 Methyl 3,6-anhydro-α-D-galactose
G0002 3,6-Anhydro-D-galactose
G0011 D-Galactose-6-O-sulfate sodium salt
G0012 D-Galactose-4-O-sulfate sodium salt
G1001 D-Glucosamine-2-N-sulfate sodium salt
G1002 D-Glucosamine-6-O-sulfate
G1003 D-Glucosamine-2-N, 6-O-disulfate sodium salt
G1004 N-Acetyl-D-glucosamine-6-O-sulfate sodium salt
G1010 D-Glucosamine-3-O-sulfate
G1013 D-Glucosamine-2-N, 3-O-sulfate sodium salt
G1031 D-Glucosamine-3, 6-di-O-sulfate sodium salt
G1032 D-Glucosamine-2-N, 3-O, 6-O-trisulfate sodium salt
G1033 N-Acetyl-D-glucosamine-3-6-di-O-sulfate sodium salt
G1035 D-Glucosamine-3,4,6-tri-O-sulfate sodium salt
G1052 N-Acetyl-D-galactosamine-6-O-sulfate sodium salt
G1054 N-Acetyl-D-galactosamine-4-O-sulfate sodium salt
G1055 D-Galactosamine-2-N-sulfate sodium salt
GL01 Methyl(tri-O-acetyl-α-D-glucopyranosyl bromide)uronate
GL02 Methyl(phenyl-2,3,4-tri-O-acetyl-1-seleno-α-D-glucopyranosyl)uronate
GL03 Methyl(p-toluyl-2,3,4-tri-O-acetyl-1-thio-α-D-glucopyranosyl)uronate
GL04 Methyl(tri-O-pivaloyl-α-D-glucopyranosyl bromide)uronate
G-N001 GlcNAc L-asparagine
G-S001 Mannosylated L-serine
G-S003 Galactosylated L-serine
G-S004 Xylosylated L-serine
G-S005 GalNAc L-serine
G-T001 Mannosylated L-threonine
G-T004 GalNAc L-threonine
G-T005 GlcNAc L-threonine
G-Y002 Galactosylated L-tyrosine
IS0233 2,5-Dideoxy-2,5-imino-D-mannitol
IS0234 Kifunensine
IS0235 α-Homonojirimycin
IS0237 Deoxymannojirimycin hydrochloride
IS0238 1,4-Dideoxy-1,4-imino-D-mannitol hydrochloride
IS0239 6-Acetomido-6-deoxycastanospermine
IS0241 Deoxygalactonojirimycin
IS0244 Calystegine A3
IS0250 (2R,3R,4R,5R)-2-(3-hydroxy-4-methoxyphenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
IS0251 (2R,3R,4R,5R)-2-(hydroxymethyl)-5-(4-hydroxyphenyl)pyrrolidine-3,4-diol
IS0263 Swainsonine
IS0298 N-Methyl trans-4-hydroxy-L-proline
IS0304 N,N-Dimethyl cis-4-hydroxy-L-proline
IS0324 N-Methyl cis-4-hydroxymethyl-L-proline
IS0350 Castanospermine
IS0401 Calystegine B3
IS0402 7,7a-Diepialexine
IS0446 N,N-Dimethyl trans-4-hydroxy-L-proline
IS0453 6-epi-Castanospermine
IS0501 Australine HCl
IS0602 3,7a-Diepialexine
IS0676 1,4-Dideoxy-1,4-imino-D-arabitol HCl
IS0756 1-Deoxynojirimycin
IS0785 1-Deoxyfuconojirimycin HCl
IS0786 1-Deoxy-L-idonojirimycin HCl
N101 N-Acetylneuraminic acid
N102 N-Glycolylneuraminic Acid
NZP402 Tetra-O-acetyl-2-acetamido-2-deoxy-β-D-mannose
NZP404 Methyl-α-galactopyranoside
PZ008 N-Acetyl-α-D-glucosamine-1-phosphate (sodium salt)
PZ009 α-D-Mannose-1-phosphate (ammonium salt)
PZ011 α-L-Fucose-1-phosphate (cyclohexylammonium salt)
PZ012 β-L-Fucose-1-phosphate (cyclohexylammonium salt)
PZ014 D-Myo-inositol-1,3,4-triphosphate (ammonium salt)
PZ015 D-Myo-inositol-1,3,5-triphosphate (ammonium salt)
PZ016 D-Myo-inositol-1,4,5-triphosphate (ammonium salt)
PZ017 D-Myo-inositol-1,3,4,5-tetraphosphate (ammonium salt)
PZ018 D-Myo-inositol-1,4,5,6-tetraphosphate (sodium salt)
PZ020 β-L-Arabinose-1-phosphate (potassium salt)
RS001 L-Cladinose
RS002 D-Desosamine
RS003 4-Amino-4-deoxy-D-glucopyranose
RS004 Forosamine
RS005 Mycaminose
RS009 6-Amino-6-deoxy-D-glucopyranose
RS010 3-Amino-3-deoxy-D-glucopyranose