14-480 RSK2, ACTIVE 10UG Merck Sigma-Aldrich
Rsk2/MAPKAP Kinase 1b Protein, active, 10 µg
Active, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.
Description
Catalogue Number 14-480
Brand Family Upstate
Trade Name
Upstate
Description Rsk2/MAPKAP Kinase 1b Protein, active, 10 µg
Overview Recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 and Pro2
Product Information
Quality Level MQ100
Applications
Application Active, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source Expressed by baculovirus in Sf21 insect cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_004586.2
Entrez Gene Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
Gene Symbol
RPS6KA3
CLS
RSK-2
RSK2
p90-RSK2
ISPK1
MRX19
HU-3
pp90RSK2
MAPKAPK1B
HU-2
RSK
S6K-alpha3
ISPK-1
Protein Target Rsk2
Purification Method Ni2+/NTA-agarose
Target Sub-Family AGC
UniProt Number
P51812
UniProt Summary FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium (By similarity).
SIZE: 740 amino acids; 83736 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Molecular Weight 88kDa
Product Usage Statements
Quality Assurance the MAPKAP Kinase 2 substrate peptide
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -70C
Packaging Information
Material Size 10 µg
Material Package Also available in 250 µg size –call for pricing and availability and reference catalog number 14-480M when ordering the 250 µg size.
Global Trade Item Number
产品目录编号 GTIN
14-480 04053252626012
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