详细内容

MMRC

千叶大学真菌医学研究中心

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       千叶大学真菌医学研究中心起源于1946年成立的千叶大学医学院腐败研究所,今年是第71个年头。1997年,经过多次改组,更名为“医学真菌学研究中心”,作为国家共享设施,并延续至今。在此期间,作为日本唯一的病原真菌和真菌传染病综合研究中心,被教育部认证为共同使用/共同研究中心“真菌传染病研究中心”和国家生物资源项目“病原微生物”核心中心、基础研究、临床研究、联合研究、人力资源开发。

        随着日本超老龄化社会的到来,除了与癌症和先进医疗相关的机会性感染外,生活习惯病和呼吸系统疾病也越来越多,难治性真菌病也越来越多。真菌感染已经成为社会性的,也非常突出。耐多药细菌的全球增加和传播仍然是一个主要威胁,但这种情况对于真菌来说也是一个严重的问题。此外,由于经济全球化和国际旅客数量的增加,我们也面临由高致病性真菌等各种高致病性微生物引起的输入传染病的威胁。基于这种情况,本中心除了迄今为止的基础研究活动外,还在推进与临床实践的合作和研究的国际化。自 2014 年以来,我们在附属医院开设了日本第一家真菌病专科门诊,自 2015 年以来,我们一直在加强我们的临床传染病研究体系,引入了儿科传染病临床研究团队。去年,它被AMED的全球问题国际科技合作计划(SATREPS)采用,并正在与巴西坎皮纳斯大学进行联合研究。

        我中心还着力于加强基础研究能力,与不同领域融合,与产业合作。因此,我们正在积极推动与千叶大学其他部门、全国大学和研究机构、海外大学和研究机构以及私营企业的联合研究。比如去年被千叶大学全球突出研究核心和领先研发计划采用,以该中心的教职工为中心,我们已经开始基因组分析、肠道菌群分析、病原微生物转录组/代谢组分析等。 . 我们还在推动对新的抗真菌药物靶点和种子化合物的探索性研究。自去年以来,我们开设了开放创新研究实验室,旨在通过与公司合作开发药物发现。未来,我们正在等待与该中心的基础和临床教员的公司联合研究的建议,不仅限于真菌感染。通过这些各种各样的共同研究,我希望不仅在大学,而且在企业中为下一代研究人员的发展做出贡献。  

       我中心将继续在日本的病原真菌、传染病和免疫领域发挥主导作用,同时灵活应对学术研究的趋势。

2017 年4月 Chihiro

Sasakawa,千叶大学真菌医学研究中心



MMRC-千叶大学菌种保藏中心目录

千叶大学菌种保藏中心目录(部分节选)

【A】

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Absidia corymbifera colonyAbsidia corymbifera microscopy-1Absidia corymbifera microscopy-2Absidia cylindrospora microscopyAcremonium kiliense colonyAcremonium kiliense microscopyActinomadura madurae SEMActinomyces israelii macro- and microcoloniesAlternaria alternata colony-1Alternaria alternata colony-2Alternaria alternata microscopy-1Alternaria alternata microscopy-2Arthrinium phaeospermum colonyArthrinium phaeospermum microscopyArthroderma benhamiae microscopyArthroderma benhamiae gymnothecium SEM-1Arthroderma benhamiae peridial hyphae SEM-2Arthroderma benhamiae peridial hyphae with spirals SEM-3Arthroderma (Microsporum) fulvum gymnotheciaArthrographis kalrae coloniesArthrographis kalrae microscopy-1Arthrographis kalrae microscopy-2Aspergillus flavus colonyAspergillus flavus conidiaAspergillus flavus conidiogenous apparatusAspergillus fumigatus colonyAspergillus fumigatus conidial headsAspergillus fumigatus conidiogenous apparatusAspergillus fumigatus phialides & conidiaAspergillus fumigatus SEMAspergillus nidulans colony-1Aspergillus nidulans colony-2Aspergillus nidulans microscopy-1Aspergillus nidulans microscopy-2Aspergillus niger colonyAspergillus niger histopathology (lung, polarizing microscopy)Aspergillus niger microscopyAspergillus terreus colonyAspergillus terreus microscopyAspergillus terreus stereoscopyAspergillus versicolor colony-1Aspergillus versicolor colony-2Aspergillosis, invasive pulmonaryAureobasidium pullulans colony-1Aureobasidium pullulans colony-2Aureobasidium pullulans microscopy

▲INDEX


【B】

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Basidiobolus ranarum colonyBasidiobols ranarum microscopyBasidiobolus ranarum zygosporesBasidiobolus ranarum ballistoconidiaBipolaris spicifera colonyBipolaris spicifera microscopyBlastomyces dermatitidis colonyBlastomyces dermatitidis colony-2Blastomyces dermatitidis mycelial formBlastomyces dermatitidis yeast-form colonyBlastomyces dermatitidis yeast-like cells

▲INDEX


【C】


Candida albicans chlamydosporesCandida albicans colonyCandida albicans germ tubeCandida dubliniensis chlamydospores-1Candida dubliniensis chlamydospores-2Candida dubliniensis colonyCandida guilliermondii colonyCandida parapsilosis colonyCandida pelliculosa ascosporesCandida tropicalis colonyChaetomium bostrycodes ascomasChaetomium bostrycodes colonyChatetomium globosum colony-1Chatetomium globosum colony-2Chatetomium globosum ascospores SEMCladophialophora bantiana colony-1Cladophialophora bantiana colony-2Cladophialophora bantiana microscopyCladophialophora carrionii colonyCladophialophora carrionii microscopy-1Cladophialophora carrionii microscopy-2Cladophialophora carrionii SEMCladosporium cladosporioides colonyCladosporium cladosporioides microscopyCladosporium herbarum colonyCladosporium sphaerospermum colonyCladosporium sphaerospermum microscopyCoccidioides immitis colony-1Coccidioides immitis colony-2Coccidioides immitis colony-3Coccidioides immitis colony-4Coccidioides immitis histopathology (lung, human)Coccidioides immitis immature spherule SEMCoccidioides immitis microscopyCoccidioides immitis smear (sputum)Coccidioides immitis spherules histopathologyCoccidioides immitis spherules SEM-1Coccidioides immitis spherule SEM-2Cokeromyces recurvatus colonyCokeromyces recurvatus microscopyConidiobolus coronatus colonyConidiobolus coronatus microscopy-1Conidiobolus coronatus microscopy-2Corynebacterium xerosis SEMCryptoccocus neofolmans capsuleCryptococcus neoformans from pigeon droppingCryptococcus neoformans matingCryptococcus neoformans basidiospore formation SEMCryptococcus neoformans TEMCryptococcus neoformans var. gattii coloniesCunninghamella bertholletiae microscopy-1Cunninghamella bertholletiae microscopy-2Curvularia lunata colonyCurvularia lunata microscopyCurvularia senegalensis microscopyCylindrocarpon lichenicola colonyCylindrocarpon lichenicola microscopy-1Cylindrocarpon lichenicola microscopy-2

▲INDEX


【E】


Emericella nidulans ascomaEmericella nidulans ascospores SEMEmericella nidulans colony with cleistotheciaEmericella rugulosa ascospores SEMEmericella striata ascospores SEMEmericella variecolor ascospores SEMEpidermophyton floccosum colony-1Epidermophyton floccosum colony-2Epidermophyton floccosum microscopy-1Epidermophyton floccosum microscopy-2Eupenicillium brefeldianum ascomata SEMEupenicillium brefeldianum ascospores SEMExophiala alcalophila coloniesExophiala alcalophila SEMExophiala dermatitidis colonies-1Exophiala dermatitidis colonies-2Exophiala dermatitidis granular form colonyExophiala dermatitidis granular form microscopyExophiala dermatitidis microscopyExophiala dermatitidis SEM-1Exophiala dermatitidis SEM-2Exophiala dermatitidis SEM-3Exophiala dermatitidis SEM-4Exophiala dermatitidis SEM-5Exophiala dermatitidis TEMExophiala jeanselmei coloniesExophiala jeanselmei microscopyExophiala jeanselmei SEMExophiala moniliae coloniesExophiala moniliae microscopy-1Exophiala moniliae microscopy-2Exophiala moniliae SEMExophiala salmonis colonyExophiala salmonis SEM-1Exophiala salmonis SEM-2Exophiala spinifera colony-1Exophiala spinifera colony-2Exophiala spinifera microscopy-1Exophiala spinifera microscopy-2Exophiala spinifera SEMExserohilum rostratum colonyExserohilum rostratum microscopy-1Exserohilum rostratum microscopy-2

▲INDEX


【F】


Filobasidiella neoformans matingFilobasidiella neoformans SEM-1Filobasidiella neoformans SEM-2Fonsecaea compacta colonyFonsecaea compacta microscopyFonsecaea pedrosoi colonyFonsecaea pedrosoi microscopy-1Fonsecaea pedrosoi microscopy-2Fonsecaea pedrosoi microscopy-3Fonsecaea pedrosoi SEM-1Fonsecaea pedrosoi SEM-2Fusarium oxysporum colonyFusarium oxysporum microscopy-1Fusarium oxysporum microscopy-2Fusarium oxysporum microscopy-3Fusarium solani chlamydosporeFusarium solani colonyFusarium solani histopathology (skin, human)Fusarium solani macroconidiaFusarium solani microconidiaFusarium solani phialides and macroconidiaFusarium verticilloides (syn. moniliforme) colonyFusarium verticilloides (syn. moniliforme) macroconidiaFusarium verticilloides (syn. moniliforme) microconidia

▲INDEX


【G】


Geotrichum candidum colonyGeotrichum candidum microscopy-1Geotrichum candidum microscopy-2Gordonia araii SEMGordonia effusa SEM

▲INDEX


【H】


Histoplasma capsulatumcolony-1Histoplasma capsulatum colony-2Histoplasma capsulatum colony-3Histoplasma capsulatum colony-4Histoplasma capsulatum histopathology (adrenal gland, human)Histoplasma capsulatum macro- and microconidia-1Histoplasma capsulatum macro- and microconidia-2Histoplasma capsulatum microconidiaHistoplasma capsulatum SEMHistoplasma capsulatum yeast formHortaea werneckii colony-1Hortaea werneckii colony-2Hortaea werneckii colony-3Hortaea werneckii microscopy-1Hortaea werneckii microscopy-2Hortaea werneckii SEM-1Hortaea werneckii SEM-2Hortaea werneckii SEM-3Hortaea werneckii SEM-4Hortaea werneckii SEM-5Hortaea werneckii SEM-6Hortaea werneckii SEM-7

▲INDEX


【L】


Lecythophora hoffmannii coloniesLecythophora hoffmannii microscopyLecythophora mutabilis coloniesLecythophora mutabilis microscopy-1Lecythophora mutabilis microscopy-2

▲INDEX


【M】


Malassezia furfur coloniesMalassezia furfur TEM by freeze-fracture replicationMalassezia pachydermatis coloniesMalassezia sp. KOH specimenMalbranchea sulfurea microscopyMicrosporum canis colony-1Microsporum canis colony-2Microsporum canis macroconidiaMicrosporum cookei microscopyMicrosporum ferrugineum coloniesMicrosporum fulvum matingMicrosporum fulvum microscopyMicrosporum fulvum teleomorphMicrosporum gypseum colony-1Microsporum gypseum colony-2Microsporum gypseum macroconidia-1Microsporum gypseum macroconidia-2Microsporum gypseum SEMMortierella isabellina colonyMortierella isabellina microscopyMortierella wolfii coloniesMucor circinelloides coloniesMucor circinelloides microscopy-1Mucor circinelloides microscopy-2Mucor hiemalis matingMucor hiemalis zygospores microscopy

▲INDEX


【N】


Neosartorya fischeri ascospores SEMNeosartorya fischeri colonyNeosartorya glabra ascospores SEMNeosartorya hiratsukae ascospores SEMNeosartorya multiplicata asci microscopyNeosartorya multiplicata ascomatal initial microscopyNeosartorya multiplicata ascospores SEMNeosartorya multiplicata aspergilla microscopyNeosartorya multiplicata colonyNeosartorya pseudofischeri colonyNeosartorya spinosa ascospores SEMNeosartorya sublevispora ascospores SEMNeosartorya sublevispora colonyNeosartorya sublevispora conidia SEMNigrospora sphaerica colonyNigrospora sphaerica microscopyNocardia asteroides colonyNocardia asteroides microcolonyNocardia brasiliensis colonyNocardia brasiliensis SEMNocardia cyriacigeorgica SEMNocardia farcinica colonyNocardia farcinica SEMNocardia nova colonyNocardia nova SEMNocardia otitidiscaviarum colonyNocardia otitidiscaviarum SEMNocardia transvalensis colonyNocardia transvalensis SEM

▲INDEX


【O】


Ochroconis gallopava coloniesOchroconis gallopava microscopyOchroconis gallopava SEMOchroconis tshawytschae microscopy

▲INDEX


【P】


Paecilomyces lilacinus colonyPaecilomyces lilacinus microscopyPaecilomyces lilacinus SEMPaecilomyces variotii colonyPaecilomyces variotii microscopyParacoccidioides brasiliensis colony-1Paracoccidioides brasiliensis colony-2Paracoccidioides brasiliensis colony-3Paracoccidioides brasiliensis dimorphismParacoccidioides brasiliensis histopathology (mucous membrane, human)Paracoccidioides brasiliensis mycelial and yeast formsParacoccidioides brasiliensis mycelial form-1Paracoccidioides brasiliensis mycelial form-2Paracoccidioides brasiliensis yeast form-1Paracoccidioides brasiliensis yeast form-2Penicillium chrysogenum colonyPenicillium chrysogenum SEMPenicillium marneffeiPenicillium marneffei colony-1Penicillium marneffei colony-2Penicillium marneffei infection histopathologyPenicillium marneffei microscopy-1Penicillium marneffei microscopy-2Penicillium marneffei SEMPenicillium marneffei yeast-like cellsPhaeoacremonium parasiticum colonyPhaeoacremonium parasiticum microscopyPhialophora parasitica colonyPhialophora parasitica microscopyPhialophora repens microscopyPhialophora repens SEMPhialophora richardsiae colonyPhialophora richardsiae microscopyPhialophora richardsiae SEM-1Phialophora richardsiae SEM-2Phialophora verrucosa colonyPhialophora verrucosa microscopyPhialophora verrucosa SEMPichia anomala ascosporesPleurostomophora repens microscopyPleurostomophora repens SEMPleurostomophora richardsiae microscopyPleurostomophora richardsiae SEM-1Pleurostomophora richardsiae SEM-2Pseudallescheria boydii ascosporesPseudallescheria boydii colony-1Pseudallescheria boydii colony-2Pseudallescheria boydii colony-3Pseudallescheria boydii conidia microscopy-1Pseudallescheria boydii cleistothecium microscopy-2Pseudallescheria boydii synnema microscopy-2Pythium insidiosum coloniesPythium insidiosum microscopy

▲INDEX


【R】


Ramichloridium schulzeri colonyRamichloridium schulzeri microscopyRhinocladiella aquaspersa colonyRhinocladiella aquaspersa microscopyRhinocladiella atrovirens colonyRhinocladiella atrovirens microscopyRhinocladiella atrovirens SEMRhizomucor pusillus colonyRhizomucor pusillus microscopy-1Rhizomucor pusillus microscopy-2Rhizopus microsporus var. rhizopodiformis colonyRhizopus microsporus var. rhizopodiformis microscopy-1Rhizopus microsporus var. rhizopodiformis microscopy-2Rhizopus microsporus var. rhizopodiformis microscopy-3Rhizopus oryzae colony-1Rhizopus oryzae colony-2Rhizopus oryzae columellaeRhizopus oryzae microscopy-1Rhizopus oryzae microscopy-2Rhizopus oryzae rhizoidsRhizopus oryzae sporangiosporesRhizopus oryzae sporangium-1Rhizopus oryzae sporangium-2Rhizopus stolonifer colony-1Rhizopus stolonifer colony-2Rhodococcus equi SEMRhodotorula mucilaginosa colonyRothia dentocariosa SEM

▲INDEX


【S】


Saccharopolyspora rectivirgula aerial hyphaeSaccharopolyspora rectivirgula micromorphologiesSaccharopolyspora rectivirgula SEMSaksenaea vasiformis colonySaksenaea vasiformis microscopyScedosporium apiospermum colony-1Scedosporium apiospermum colony-2Scedosporium apiospermum colony-3Scedosporium apiospermum microscopy-1Scedosporium apiospermum microscopy-2Scedosporium apiospermum microscopy-synnemaScedosporium apiospermum SEM-1Scedosporium apiospermum SEM-2Scedosporium prolificans colony-1Scedosporium prolificans colony-2Scedosporium prolificans microscopySchizophyllum commune colony-1Schizophyllum commune colony-2Schizophyllum commune fruitbodySchizophyllum commune secondary myceliumScopulariopsis brevicaulis colonyScopulariopsis brevicaulis microscopyScopulariopsis brevicaulis SEMSporothrix schenckii colony and yeast formSporothrix schenckii microscopySporothrix schenckii SEM-1Sporothrix schenckii SEM-2Stachybotrys chartarum colonyStachybotrys chartarum microscopy-1Stachybotrys chartarum microscopy-2Syncephalastrum racemosum colonySyncephalastrum racemosum microscopy-1Syncephalastrum racemosum microscopy-2

▲INDEX


【T】


Talaromyces flavus ascomata SEMTalaromyces flavus ascospores SEMTalaromyces stipitatus ascosporesTalaromyces wortomannii ascospores SEMTalaromyces wortomannii colonyTrichoderma sp. colonyTrichoderma sp. microscopyTrichophyton ajelloi coloniesTrichophyton ajelloi microscopyTrichophyton mentagrophytes colony-1Trichophyton mentagrophytes colony-2Trichophyton mentagrophytes microscopyTrichophyton mentagrophytes SEMTrichophyton mentagrophytes var. erinacei colonyTrichophyton mentagrophytes var. erinacei microscopyTrichophyton rubrum colony-1Trichophyton rubrum colony-2Trichophyton rubrum colony-3Trichophyton rubrum microscopy-1Trichophyton rubrum microscopy-2Trichophyton schoenleinii colony-1Trichophyton schoenleinii colony-2Trichophyton schoenleinii microscopyTrichophyton simii microscopyTrichophyton tonsurans colony-1Trichophyton tonsurans colony-2Trichophyton tonsurans microscopy-1Trichophyton tonsurans microscopy-2Trichophyton tonsurans microscopy-3Trichophyton verrucosum colonyTrichophyton verrucosum microscopy-1Trichophyton verrucosum microscopy-2Trichophyton violaceum colony-1Trichophyton violaceum colony-2Trichosporon asahii colonyTrichosporon inkin colonyTsukamurella pulmoris SEM

▲INDEX


【U】


Ulocladium atrum SEM-1Ulocladium atrum SEM-2Ulocladium botrytis colonyUlocladium botrytis microscopy

▲INDEX


【V】


Veronaea botryosa coloniesVeronaea botryosa microscopyVeronaea botryosa SEM

▲INDEX


【Z】


Zygorhynchus exponense colonyZygorhynchus exponense microscopy-1Zygorhynchus exponense microscopy-2Zygorhynchus exponense microscopy-3




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