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NIBSC--英国国家生物制品检定所,英国药检所

英国国家生物制品检定所

National Institute for Biological Standards and Control

NIBSC

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英国国家生物制品检定所是WHO的一个国际标准品供应中心实验室,它的核心工作是制备、保存和分发WHO用于检测全球生物制品质量的标准品。

NIBSC制备的流感毒株和检测抗原、抗血清标准品,保障了各厂家顺利的研究和生产。

NIBSC为众多组织提供科学建议和专业知识方面发挥着关键作用,主要包括:

生物医药制造商、国家监管机构、英国政府和欧洲机构、世界卫生组织和联合国机构等。

NIBSC提供生物医学研究领域大量的国际标准物质,参照品以及试剂。其主要产品如下:


1.生物标准物质、艾滋病试剂中心供应的试剂以及CJD资源中心产品

NIBSC在准备,评估和分发国际生物标准和其他生物参考材料方面发挥着重要的国际作用,为世界卫生组织(WHO)提供了90%以上的这些材料。

生物标准物质包括大量的细胞因子/生长因子、内毒素、免疫球蛋白与免疫血清、蛋白激素及内分泌因子和大量的诊断试剂以及疫苗等。

除了WHO标准外,NIBSC还拥有2,000多种由艾滋病试剂中心(CFAR)管理的试剂。CJD资源中心提供用于研究和开发Creutzfeldt-Jakob病(CJD)诊断测试的特征材料。


2.流感产品以及生物药品

NIBSC的流感资源中心在流感疫苗的生产与标准化中起到重大作用,流感疫苗的研发与生产的关键问题在于流感病毒存在着极高的突变率,用于流感疫苗研发和生产的病毒株需要每隔一段时间进行更新,在WHO推荐御用疫苗生产和研发流感毒株选择上起到了关键作用。NIBSC为客户提供大量的最新候选流感疫苗、病毒等相关产品。

生物药品是非常复杂的产品,正因为如此,大多数生物药品在投入使用前都会经过独立测试。在英国和欧盟,生物产品在投入使用前会先提交到欧盟的其中一个 OMCL机构进行测试。确保疫苗的安全性尤其重要,因为它们将在全国范围内的免疫活动中用于大量健康的个人。通过研究院的测试和评估工作,NIBSC的科学家们帮助其确保了生物产品的安全性和有效性,同时也帮助缩短了将新产品投入到临床使用的时间。新产品,如最新一代复合疫苗,需要采取新颖的方法加以控制。作为基因革命带来的影响之一,生物产品在数量和复杂程度上的潜在大幅增长也需要有更为彻底的控制战略方案。


3.英国干细胞库供应产品以及病毒研究的质控血清

NIBSC提供大量病毒研究用的质控血清以及UKSCB的多种人/鼠干细胞株。


WHO international standards

订货编号   国际标准品名称及描述

00/410    MAPREC assay of poliovirus type 1 (Sabin).100% 480-A, 525-C DNA(1st International Reference Preparation)    

00/416    Low Mutant Virus Reference for MAPREC assay of poliovirus type 1 (Sabin)(1st International Reference Preparation)    

00/418    MAPREC assay of poliovirus type 1 (Sabin) (1st International Standard)    

00/422    High Mutant Virus Reference for MAPREC assay of poliovirus type 1 (Sabin)(1st International Reference Preparation)    

00/464    Streptokinase (3rd International Standard 2001)    

00/562    Hepatitis A Virus for Nucleic Acid Amplification Techniques(2nd International Standard)    

00/572    Interferon Beta (Human, rDNA, Glycosylated) (3rd International standard)    

007SP    Human Anti-Pneumococcal capsule Reference Serum (1st International Standard)    

01/420    Interleukin-17 (Human rDNA derived)(International Reference Reagent)    

01/528    Oral Poliovaccine Sabin Type 1 reference strain [LS-c, 2ab strain] (Panel of 5 ampoules)    

01/530    Oral Poliovaccine Sabin Type 2 reference strain (Panel of 5 ampoules)    

01/532    Oral Poliovaccine Sabin Type 3 reference strain (Panel of 5 ampoules)    

01/572    Anti-D Immunoglobulin(2nd International Standard)    

01/580    Thrombin, human(2nd International Standard)    

01/600    Anti-Toxoplasma IgG, Human(International Standard)    

01/602    Anti-Parvovirus B19, plasma, human(2nd International Standard)    

02/168    Prekallikrein Activator (PKA), Human(2nd International Standard)    

02/186    Anti-Dengue Virus Types 1+2+3+4, Human (International Reference Reagent)    

02/206    Factor XIII Plasma, Human (1st International Standard)    

02/210    HIV (antibody), 1st International Reference Panel    

02/226    IVIG negative control for use with IVIG + anti-D(International Reference Reagent)    

02/228    IVIG + anti-D for use with negative control IVIG(International Reference Reagent)    

02/254    Insulin-like Growth Factor-1, recombinant, human, for immunoassay(1st International Standard)    

02/286    Vascular Endothelial Growth Factor 165 (VEGF165)(recDNA, human sequence)(International Reference Reagent)    

02/306    Polio Virus Sabin Types 1, 2 and 3(2nd International Reference Reagent)    

02/342    Protein C Plasma, Human(2nd International Standard)    

03/116    Blood Coagulation Factor V, Plasma Human (1st International Standard)    

03/148    Keratinocyte growth factor (KGF, FGF-7)(24-163)(1st International Reference Reagent)    

03/150    Keratinocyte Growth Factor (KGF,FGF-7)(1st International Reference Reagent)    

03/152    Anti-HPA-1a (International Standard)    

03/164    Anti-B minimum potency reference preparation(International Standard)    

03/178    Vitamin B12, Serum Folate and holoTC (International standard)    

03/188    Anti-A minimum potency reference preparation(International Standard)    

03/190    Anti-HPA-3a(minimum potency)(International Reference Reagent)    

03/192    Thyroid-Stimulating Hormone, Recombinant, Human, for Bioassay (1st International standard)    

03/200    Interleukin - 18 (Human rDNA derived)(International Reference Reagent)    

03/228    Protein S, Plasma, Human(2nd International Standard)    

03/262    Hepatitis B Surface Antigen subtype adw2, genotype A (International Reference Panel)    

04/150    Tetanus Toxoid For Flocculation Test(2nd International Standard)    

04/166    TNF-related Apoptosis-Inducing Ligand (trail), Human, rDNA-derived(1st International Reference Reagent)    

04/176    Plasmodium falciparum DNA for NAT Assays(1st International Standard)    

04/224    Factor V Leiden, Human gDNA, 1st International Genetic Reference Panel 2004    

04/252    Protein C Concentrate, Human(1st International Standard)    

05/106    Anti-HPA-1a minimum potency reagent(2nd International Reference reagent)    

05/112    Low Molecular Weight Heparin for Molecular Weight Calibration (2nd International Standard).    

05/122    Syphilitic plasma IgG (human)(1st International Standard)    

05/130    Prothrombin Mutation G20210A, Human gDNA(1st International Genetic Reference Panel 2005)    

05/134    Anti-human papillomavirus type 16 serum (1st International Standard)    

05/162    Alpha-1-Antitrypsin, plasma derived(1st International standard)    

06/124    Monoclonal Antibody for Serotyping Bordetella pertussis Fimbrial Antigen 2 (1st International Standard)    

06/128    Monoclonal Antibody for Serotyping Bordetella pertussis Fimbrial Antigen 3 (1st International Standard)    

06/140    Pertussis Antiserum(human)1st IS-WHO international Standard.    

06/142    Pertussis Antiserum (Human) 1st WHO Reference Reagent    

06/166    Antithrombin Concentrate, Human (3rd International Standard)    

06/202    Human Papillomavirus (HPV) Type 16 DNA (1st International Standard)    

06/206    Human Papillomavirus (HPV) Type 18 DNA (1st International Standard)    

07/150    Human Plasma Anti-Influenza H5N1 (1st International Standard)    

07/164    Anti-hepatitis B surface antigen(Anti-HBs) immunoglobulin (2nd International Standard)    

07/202    Recombinant soluble transferrin receptor (rsTfR)(1st WHO Reference Reagent)    

07/216    Diphtheria Toxoid (Adsorbed) (4th International Standard)    

07/222    RhD/SRY Plasma DNA sensitivity standard (1st International Reference Reagent)    

07/228    Blood Coagulation Factor VIIa, Concentrate, Human, 2nd International Standard”    

07/270    BCG Vaccine of Danish 1331 sub-strain (1st WHO Reference Reagent)    

07/272    BCG Vaccine of Tokyo 172 sub-strain(1st WHO Reference Reagent)    

07/274    BCG Vaccine of Russian BCG-I sub-strain(1st WHO Reference Reagent)    

07/306    Anti-A and anti-B in IVIG: Positive control for haemagglutination tests (International Reference Reagent)    

07/308    Anti-A and anti-B in IVIG Negative control for haemagglutination tests (International Reference Reagent)    

07/310    Anti-A and anti-B in IVIG: Limit reference preparation(International Reference Reagent)    

07/316    Blood Coagulation Factor VIII and Von Willebrand Factor in Plasma (6th I.S.)    

07/328    Unfractionated Heparin (6th I.S.)    

07/350    Blood Coagulation Factor VIII Concentrate (8th I.S.)    

07/364    Chorionic Gonadotrophin, (5th IS)    

08/150    HIV-2 RNA(1st International Standard)    

08/158    Fragile X Syndrome gDNA (1st International Genetic Reference Panel)    

08/160    Haemophilia A, Intron-22 inversion, gDNA, (1st International Genetic Reference Panel)    

08/204    Thyroid Stimulating Antibody (2nd I.S.)    

08/214    Meningococcal Serogroup C polysaccharide (1st International Standard)    

08/218    Tetanus Toxoid Adsorbed (4th International Standard)    

08/230    Streptodornase (2nd International Standard)    

08/256    C1- Inhibitor, Concentrate (1st International Standard)    

08/258    Antithrombin, Plasma (3rd International Standard)    

08/262    C1 Inhibitor (Plasma)(1st International Standard)    

08/266    Sex Hormone Binding Globulin.(2nd International Standard)    

08/270    Anti-A and Anti-B in IVIG: Positive and Negative control panel(1st International Reference Reagent) (2 ampoules of 07/306 and 2 ampoules of 07/308)    

08/282    Follicle-Stimulating Hormone, human, recombinant, for bioassay (2nd International Standard)    

09/110    Parvovirus B19 DNA Nucleic Acid Amplification Technology(NAT) based assays Genotype Panel(1st International Standard)    

09/136    Granulocyte Colony Stimulating Factor (Human, rDNA Derived)(2nd International Standard)    

09/138    Genetic Reference Panel, for the quantitation of BCR-ABL translocation by RQ-PCR (1st I.S.)    

09/140    Prader Willi & Angelman Syndromes, Human gDNA,(1st International Genetic Reference Panel)    

09/154    Clostridium sordellii (Gas-gangrene) Antitoxin, Equine,(1st International standard)    

09/162    Human Cytomegalovirus (HCMV) for Nucleic Acid Amplification Techniques (1st International Standard)    

09/172    Blood coagulation Factors II, VII, IX, X Plasma (4th International Standard 2010)    

09/182    VWF Factor Concentrate (2nd International Standard)    

09/186    Chagas (anti-Trypanosoma cruzi II) antibody in human plasma(1st International Standard)    

09/188    Chagas (anti-Trypanosoma cruzi I) antibody in Human Plasma (1st International Standard)    

09/234    Transforming Growth Factor-BETA 3 (Human, rDNA derived TGF-ß 3) (1st International Standard)    

09/242    Fibrinogen Concentrate (B)(2nd International Standard)    

09/260    Epstein-Barr Virus for Nucleic Acid Amplification Techniques(1st International Standard)    

09/264    Fibrinogen Plasma (D)(3rd International Standard)    

09/284    Anti-Human Neutrophil Antibody 1a WHO Reference Reagent    

09/296    Pro-Insulin, human (1st International Standard)    

10/140    Anti-human papillomavirus[HPV] 18 serum (1st International Standard)    

10/164    Oral Poliovaccine Sabin Type 1 reference strain [LS-c, 2ab strain].    

10/166    Oral Poliovaccine Sabin Type 2 reference    

10/168    Oral Poliovaccine Sabin Type 3 reference    

10/176    Interleukin-29 (Interferon Lamda 1)    

10/178    Endotoxin (3rd International Standard)    

10/198    Anti-malaria (Plasmodium falciparum) human serum(1st International Reference Reagent)    

10/202    Influenza antibody (Human) to A/California/7/2009 'like' (H1N1v) virus (2nd International Standard)    

10/232    Genomic DNA for blood group genotyping RBC1(AR1R1)(International Reference Reagent)    

10/234    Genomic DNA for blood group genotyping RBC12 (ODpsi)(International Reference Reagent)    

10/236    Genomic DNA for blood group genotyping RBC4(OR1R2)(International Reference Reagent)    

10/238    Genomic DNA for blood group genotyping RBC5(Brr)(International Reference Reagent)    

10/242    Toxoplasma gondii DNA Nucleic Acid Amplification Techniques(1st International Standard)    

10/252    Factor VII Concentrate(2nd International Standard)    

10/262    Diphtheria Antitoxin Human IgG(1st International Standard)    

10/266    4th WHO International Standard for HBV DNA for NAT    

10/272    BCG vaccine of Moreau-RJ sub-strain(1st International Reference Reagent)    

10/286    Follicle Stimulating Hormone, Luteinizing Hormone human, urinary for bioassay(5th International Standard)    

11/126    Factors II and X Concentrate (4th International standard)    

11/170    Erythropoietin, recombinant, for Bioassay (3rd International Standard)    

11/176    (3rd International Standard) Low Molecular Weight Heparin    

11/184    High Molecular Weight Urokinase(2nd International Standard)    

11/214    Blood Group Genotyping Reference Panel ((International Reference Reagent)    

11/216    Chagas Antibody Reference Panel ( 1st International Standard)    

11/234    Immunoglobulin E(IgE) human serum (3rd International Standard)    

11/236    Factor XIa (1st International Reference Reagent)    

12/104    International Standard for IPV 12/104 (3rd International Standard)    

12/154    Tumour Necrosis Factor alpha (human rDNA derived)(3rd International Standard)    

12/188    Pegylated Granulocyte Colony Stimulating Factor (Human, rDNA derived) (International Standard)    

12/208    Parvovirus B19 (3rd International Standard)    

12/224    HIV-1 NAT subtypes (Main)(2nd International Reference Panel Preparation)    

12/226    HBsAg (HBV genotype B4, HBsAg subtypes ayw1/adw2)(3rd International Standard)    

12/244    Vi polysaccharide of C freundii WHO 1st International Standard    

12/252    ADAMTS 13 Plasma (1st International Standard)    

12/306    Haemophilus Influenzae Polysaccharide Polyribosyl Ribitol Phosphate (PRP)(2nd International Standard)    

13/100    Activated Blood Coagulation Factor XI (FXIa), Human (1st International Standard)    

13/122    Erythropoietin Antibody Reference Panel Negative Control Antibody (1st WHO Reference Panel)    

13/132    Antibodies, Human, to Toxoplasma gondii (4th International Standard).    

13/146    C-Peptide, Human (1st International Standard).    

13/172    Lupus Anticoagulant (1st International Reference Panel)    

13/204    TNF Rec II- FC Fusion protein (1st International Standard)    

13/206    Plasmin (4th International Standard)    

13/212    Diphtheria Toxoid for use in Flocculation Test (3rd International Standard)    

13/214    HIV-1 Circulating Recombinant Forms RNA (1st International Reference Panel)    

13/238    Anti-EV71 serum LOW (WHO International Reference Reagent)    

13/246    Meningococcal serogroup A polysaccharide (1st WHO International Standard).    

14/114    JC Virus (JCV) DNA (1st International Standard)    

14/140    1st International Standard for Anti EV71 Serum Human    

14/148    Human Blood Factor IX Concentrate (5th International Standard).    

14/150    Hepatitis C virus (HCV) For nucleic acid amplification techniques (5th International standard 2015)    

14/156    Meningococcal group X polysaccharide (1st WHO International Standard)    

14/210    Biological activities of Rituximab WHO 1st International Standard    

14/212    BK Virus (BKV)(1st International Standard)    

14/300    High titre anti-A and anti-B in serum (WHO Reference Reagent).    

14/316    Factor IX activated (FIXa) 2nd WHO International Standard    

15/102    Activated Blood Coagulation Factor X (FXa), Human    

15/106    Ancrod    

15/126    Bordetella pertussis toxin (20μg). (2nd International Standard)    

15/136    EBOV RNA NP-VP35-GP in-run control    

15/138    EBOV RNA VP40-L in-run control    

15/174    Lupus (oligo-specific) anti-dsDNA antibodies WHO Reference Reagent    

15/180    Blood Coagulation Factor XI, 2016 Plasma Human (2nd International Standard). Blood Coagulation Factor XII, 2017 Plasma, Human (1st International Standard)    

15/220    Anti-EBOV plasma, human (WHO Reference Reagent)    

15/222    EBOV RNA NP-VP35-GP (WHO Reference Reagent)    

15/224    EBOV RNA VP40-L (WHO Reference Reagent)    

15/240    Erythropoietin Antibody Reference Panel A (1st WHO Reference Panel)    

15/242    Erythropoietin Antibody Reference Panel B (1st WHO Reference Panel)    

15/262    Anti- EBOV Convalescent Plasma Pool - Sierra Leone (International Reference Reagent)    

15/266    HHV-6 Virus 1st WHO International Standard    

15/304    Parathyroid hormone 1-34, recombinant, human, 2nd WHO International Standard    

16/120    WHO 1st International Reference Panel for Genomic JAK2 V617F    

16/126    Native Vi polysaccharide (S. Typhi)    

16/138    Anti-Typhoid capsular Vi polysaccharide IgG (Human) 1st WHO International Standard    

16/166    Diphtheria Antitoxin Equine DI.    

16/170    Infliximab(1st International Standard)    

16/194    HIV-1 RNA (4th International Standard)    

16/250    1st International Reference Panel for genomic KRAS codons 12 and 13 mutations    

16/284    Antiserum to Respiratory Syncytial Virus WHO 1st International Standard    

16/344    WHO Anti-EBOV Convalescent Plasma (International Reference Panel)    

16/376    Plasmodium falciparum antigens (1st International Standard)    

2BADS    Anti-Brucella Abortus Serum, Bovine (International Standard)    

2CPBETAAT    Clostridium Perfringens Beta Antitoxin (2nd International Standard)    

2CPEPAT    Clostridium Perfringens Epsilon Antitoxin (2nd International Standard)    

59/016    Corticotrophin (ACTH), Porcine (3rd International Standard)    

61/001    Botulinum Antitoxin Equine Type D (1st International Standard)    

62/001    Serum Gonadotrophin, Equine (2nd International Standard)    

65/093    Anti-Thyroglobulin Serum, Human (International Reference reagent)    

67/086    Immunoglobulins G, A, M Serum Human (International Standard)    

68/356    Renin, Human (International Standard)    

69/194    Glucagon, Porcine (First International Standard)    

73/545    Placental Lactogen, Human (International Reference Preparation)    

73/601    Carcinoembryonic Antigen (CEA), Human (1st International Reference Preparation)    

74/586    Corticotrophin (ACTH), Porcine (International Working Standard)    

75/551    Chorionic Gonadotrophin beta Subunit, Human (International Reference Preparation)    

75/569    Chorionic Gonadotrophin alpha subunit, Human (International Reference Preparation)    

76/522    Opacity 5IRP WHO International Standard    

76/575    Oxytocin(4th International Standard)    

77/512    Lysine Vasopressin(1st International Standard)    

78/543    Kininogenase (Porcine, Pancreatic) (Formerly 1st International Standard)    

78/554    Luteinizing Hormone, Pituitary, alpha subunit (International Standard)    

78/556    Luteinizing Hormone, Pituitary, beta subunit (International standard)    

79/500    Parathyroid Hormone, Human (1st International Ref. Preparation)    

80/505    Growth Hormone, Human, Pituitary. WHO International Standard    

80/590    Tetracosactide. International Ref. Preparation    

81/535    Luteinizing Hormone, Human, Pituitary (3rd International Standard)    

81/565    Thyroid Stimulating Hormone, Human. WHO International Standard    

82/518    Dermatophagoides Pteronyssinus Extract. WHO International Standard    

82/520    Timothy Pollen Extract. WHO International Standard    

82/585    Anti Poliovirus serum types 1,2 and 3 (3rd International Standard)    

82/632    Parathyroid Hormone, Bovine. WHO International Standard    

83/500    Insulin, Human. WHO International Standard    

83/501    Beta Thromboglobulin, Purified Human. WHO International Standard    

83/505    Platelet Factor 4 Human, Purified. WHO International Standard    

83/511    Insulin, Bovine. WHO International Standard    

83/514    Interferon alpha-1D, (Human rDNA derived) WHO International Standard    

83/515    Insulin, Porcine. WHO International Standard    

83/573    Prolactin, Human (4th WHO International Standard.)    

83/575    Follicle Stimulating Hormone, Pituitary. WHO International Standard    

84/510    C- Peptide of Human Insulin    

84/514    Proinsulin, Bovine. International Ref. Preparation    

84/522    Birch Pollen Extract. WHO International Standard    

84/528    Proinsulin, Porcine. International Ref. Reagent    

84/581    Short Ragweed Pollen Extract. WHO International Standard    

84/611    Proinsulin, Human    

84/614    Calcitonin, ASU 1-7 Eel Calcitonin Analogue (Elcatonin) WHO International Standard    

84/685    Dog (Canis Familiaris) Hair Dander Extract. WHO International Standard    

85/506    C-Reactive Protein, Human. WHO International Standard    

85/616    Haemoglobin F Lysate, Raised. WHO Reference Reagent    

85/669    Atrial Natriuretic Factor, Human. WHO International Standard    

86/500    Interleukin- 2 (Human, rDNA derived)(2nd International Standard)    

86/632    Interleukin-1 alpha (Human rDNA derived) WHO International Standard    

86/680    Interleukin-1 beta (Human, rDNA derived) WHO International Standard    

86/690    Inhibin, Porcine WHO International Standard    

87/640    Tumour Necrosis Factor beta (Human, rDNA derived) WHO Reference Reagent    

88/556    Calcitonin, Eel WHO International Standard    

88/638    Thyroxine-binding globulin. WHO International Standard    

88/646    Granulocyte Macrophage Colony Stimulating Factor (Human, rDNA derived) WHO International Standard    

88/656    Interleukin-4 (Human, rDNA derived) WHO International Standard    

89/512    Macrophage Colony Stimulating Factor (CSF-1) (Human rDNA derived) WHO International Standard    

89/520    Interleukin-8 (Human, rDNA derived) WHO International Standard    

89/548    Interleukin-6 (Human, rDNA derived) WHO International Standard    

89/620    Calcitonin, Human. WHO International Standard    

89/666    Haemoglobin A2 Lysate, Raised. WHO Reference Reagent    

90/530    Interleukin-7 (Human, rDNA derived) WHO Reference Reagent    

90/534    Mumps Vaccine (Live) WHO Reference Reagent    

90/586    Interleukin-5 (Human, rDNA derived) WHO Reference Reagent    

90/636    HIV-1 P24 Antigen WHO International Standard    

90/712    Basic Fibroblast Growth Factor (Human, rDNA derived) WHO International Standard    

91/510    Interleukin-3 (Human, rDNA derived) WHO International Standard    

91/530    Epidermal Growth Factor (Human, rDNA derived) WHO International Standard    

91/550    Epidermal Growth Factor (1-52) (Human, rDNA derived) WHO Reference Reagent    

91/554    Insulin-like growth Factor 1 WHO International Standard    

91/624    Inhibin A, Human, recombinant WHO International Standard    

91/626    Activin A, Human, Recombinant. WHO Reference Reagent    

91/678    Interleukin-9 (Human,rDNA derived) WHO Reference Reagent    

91/682    Stem Cell Factor (Human rDNA derived) WHO Reference Reagent    

91/688    Rubella Vaccine (Live) 1st International Reference Reagent    

92/510    Follicle Stimulating Hormone, Human, recombinant. WHO International Standard    

92/512    Follicle Stimulating Hormone, urofollitropin Human Urinary WHO International Standard    

92/648    Measles Vaccine (Live) 2nd International Reference Reagent    

92/654    Plasminogen Activator Inhibitor-1 (PAI-1), plasma Human WHO International Standard    

92/680    Serum amyloid A protein. WHO International Standard    

92/788    Interleukin-11 (Human, rDNA derived) WHO Reference Reagent    

93/556    Nerve Growth Factor (Human, rDNA derived) WHO Reference Reagent    

93/562    Leukaemia Inhibitory Factor (Human, rDNA derived) WHO Reference Reagent    

93/564    Oncostatin M (Human, rDNA derived) WHO Reference Reagent    

93/574    Bone morphogenetic Protein-2 (Human, rDNA derived) WHO Reference Reagent    

93/722    Interleukin-10 (Human rDNA derived) WHO Reference Reagent    

94/532    Pertussis Vaccine (Whole Cell) WHO International Standard    

94/572    Ferritin, Human, recombinant. WHO International Standard    

94/622    Interleukin-13 (Human, rDNA derived) WHO Reference Reagent    

94/674    Thyroid Stimulating Hormone, Human recombinant WHO Reference Reagent    

94/684    Ciliary Neurotrophic Factor (Human, rDNA derived) WHO Reference Reagent    

94/728    Platelet-derived Growth Factor-BB (Human, rDNA derived) WHO International Standard    

94/730    Tissue Plasminogen Activator (tPA) Antigen in Plasma WHO International Standard    

94/754    Interferon Omega (Human, rDNA derived) WHO International Standard    

94/784    Interferon alpha (Human, leukocyte derived)WHO International Standard    

94/786    Interferon alpha Concensus Sequence (Human rDNA derived) WHO International Standard    

94/790    MAPREC analysis of Poliovirus type 3 (Sabin). Synthetic DNA 100% 472-C WHO International Standard    

95/522    Anti-HBc (Anti-hepatitis B core antigen) WHO International Standard    

95/528    Folate, Whole Blood Haemolysate WHO International Standard    

95/542    MAPREC analysis of Poliovirus type 3 (Sabin) Synthetic DNA 0.9% 472-C WHO International Standard    

95/544    Interleukin-12 (Human, rDNA derived) WHO Reference Reagent    

95/554    Interleukin-15 (Human, rDNA derived) WHO Reference Reagent    

95/566    Interferon alpha-2b (Human, rDNA derived) WHO International Standard    

95/568    Interferon Alpha n1 (Human lymphoblastoid cell derived) WHO International Standard    

95/572    Interferon alpha-1/8 (Human, rDNA derived) WHO International Standard    

95/574    Interferon Alpha n3 (Human, leukocyte derived) WHO International Standard    

95/580    Interferon alpha-2c (Human, rDNA derived) WHO International Standard    

95/584    Anti-hepatitis E Serum, Human WHO Reference Reagent    

95/646    Parathyroid Hormone 1-84, human, recombinant (1st International Standard)    

95/650    Interferon alpha-2a (Human, rDNA derived) WHO International Standard    

96/532    FMS-like tyrosine kinase 3 ligand (Human, rDNA derived) WHO Reference Reagent    

96/534    Brain-derived Neurotrophic Factor (Human, rDNA derived) WHO Reference Reagent    

96/538    Insulin-like growth Factor-II (Human rDNA derived) WHO Reference Reagent    

96/556    Hepatocyte Growth Factor/Scatter Factor (precursor), (Human rDNA derived) WHO International Standard    

96/564    Hepatocyte Growth Factor/Scatter Factor (Human, rDNA derived) WHO Reference Reagent    

96/572    MAPREC analysis of Poliovirus type 3 (Sabin) Low virus reference 0.7%472-C WHO Reference Reagent    

96/578    MAPREC analysis of Poliovirus type 3 (Sabin) High virus reference 1.1%472-C WHO Reference Reagent    

96/602    Luteinizing Hormone, Human, recombinant WHO International Standard    

96/666    Anti-Human Globulin International Reference Reagent    

96/668    Prostate Specific Antigen (free) WHO International Standard    

96/784    Inhibin B, Human WHO Reference Reagent    

97/550    Islet Cell Antibodies WHO Reference Reagent    

97/562    Blood Coagulation Factors IXa Concentrate, Human, recombinant(1st I.S.)    

97/594    Leptin, Human, Recombinant WHO International Standard    

97/626    Leptin, Mouse, Recombinant WHO International Standard    

97/642    Bordetella pertussis anti serum (mouse) 1RR    

97/646    Anti-Hepatitis A Immunoglobulin, Human (W1041) WHO International Standard    

97/648    Anti-Measles serum (3rd International Standard)    

97/714    Prolactin, Human, recombinant. WHO Reference Reagent    

97/756    MAPREC analysis of Poliovirus type 2 (Sabin), low virus reference 0.65%481-G. WHO Reference Reagent    

97/758    MAPREC analysis of Poliovirus type 2 (Sabin) Synthetic DNA 0.67%481-G WHO International Standard    

98/524    MAPREC analysis of Poliovirus type 2 (Sabin) Synthetic DNA, 100%481-G WHO International Standard    

98/574    Somatropin WHO International Standard    

98/580    Prolactin Human, recombinant, glycosylated WHO Reference Reagent    

98/582    Prolactin, Human, recombinant, non-glycosylated WHO Reference Reagent    

98/586    Calcitonin, Salmon. WHO International Standard    

98/596    MAPREC analysis of Poliovirus type 2 (Sabin), high virus reference 1.21% 481-G. WHO Reference Reagent    

98/708    Haemiglobincyanide WHO International Standard    

98/714    Tissue Plasminogen Activator, Human, Recombinant WHO International Standard    

99/616    Yellow Fever Vaccine. WHO International Standard    

99/642    Chorionic Gonadotrophin, nicked, human. WHO Reference Reagent    

99/650    Chorionic Gonadotrophin, beta subunit, human. WHO Reference Reagent    

99/666    Anti-HPA-5b (Minimum Potency) WHO Reference Reagent    

99/688    Chorionic Gonadatrophin, intact, Human. WHO Reference Reagent    

99/692    Chorionic Gonadotrophin, nicked beta subunit, Human WHO Reference Reagent    

99/708    Chorionic Gonadatrophin, beta core fragment, Human WHO Reference Reagent    

99/720    Chorionic Gonadotrophin, alpha subunit, Human (purified)    

99/836    Anti-D Minimum Potency Standard for blood grouping reagents WHO International Standard    

AFP    Alpha-Foetoprotein. WHO International Standard    

B2M    Beta-2 Microglobulin. WHO International Standard    

BUSB    Botulinum Antitoxin Equine Type B. WHO International Standard    

CDS    Anti-Canine Distemper Serum. WHO International Standard    

CHAN    Cholera Antitoxin, Goat. WHO International Standard    

CHS    Anti-Canine Hepatitis Serum    

COT    Clostridium novyi (alpha) Toxoid. WHO Reference Reagent    

CWBETATD    Clostridium Welchii (Perfringens)(Beta) Toxoid CwBT WHO Reference Reagent    

CWEPSILTD    Clostridium Welchii (Perfringens)( Epsilon) Toxoid CwDT WHO Reference Reagent    

DY    Anti-Dysentery (shiga) serum, Equine. WHO International Standard    

JNIH-3    Acellular Pertussis Vaccine - 1st IS.    

JNIH-5    Bordetella pertussis toxin (PT) 1st IS    

MGDS    Anti-Mycoplasma gallisepticum Serum. WHO Reference Reagent    

NDS    Anti-Newcastle Disease Serum. WHO International Standard    

NVIA    Newcastle Disease Vaccine (Inactivated) WHO International Standard    

OE    Gas Gangrene Antitoxin (Cl. novyi), Equine WHO International Standard    

PE    Gas Gangrene Antitoxin (Cl. Perfringens alpha antitoxin) Equine WHO International Standard    

PPDA    Purified Protein Derivative (PPD) of M Avium Tuberculin WHO International Standard    

PPDBOV    Purified Protein Derivative (PPD) of Bovine Tuberculin WHO International Standard    

PPDT    Purified Protein Derivative (PPD) of M. Tuberculosis Tuberculin WHO International Standard    

QF    Anti-Q Fever Serum, Bovine WHO International Standard    

RBT/16    Thromboplastin, Rabbit, Plain 5th International Standard 2016.    

RTF/16    Thromboplastin, Human, Recombinant, Plain 5th International Standard 2016.    

RUBI-1-94    Anti-rubella Immunoglobulin, Human WHO International Standard    

SES    Swine Erysipelas Serum (anti-N) WHO Reference Reagent    

SFS    Anti-Swine Fever Serum WHO International Standard    

SMV    Smallpox Vaccine WHO International Standard    

SPDS-S2    Anti-Salmonella Pullorum Serum (Std. Form S) WHO International Standard    

SPDS-V    Anti-Salmonella Pullorum Serum (Variant Form V) WHO International Standard    

SPLS    Anti-Staphylococcal P-V Leucocidin serum, Equine WHO Reference Reagent    

STA    Staphylococcus Alpha Antitoxin, Equine WHO International Standard    

STT    Diphtheria (Schick) Test Toxin WHO International Standard    

TILI    Anti-tick borne encephalitis serum (Louping Ill) WHO International Standard    

TISA    Anti-tick borne encephalitis serum (Sophyn & Absettarov) WHO International Standard    

TYVK    Typhoid Vaccine (acetone-inactivated) WHO International Standard    

TYVL    Typhoid Vaccine (heat-phenol-inactivated) WHO International Standard    

VI    Gas Gangrene Antitoxin (Cl. Septicum), Equine WHO International Standard    

W1004    Anti-C complete blood typing serum,human WHO International Standard    

W1005    Anti-E complete blood typing serum, human WHO International Standard    

W1007    Anti-c Incomplete blood typing serum, human WHO International Standard    

W1044    Anti-Varicella zoster immunoglobulin WHO International Standard    

W1062    Anti smooth muscle(anti actin) autoantibody. WHO Reference Reagent    

W1063    Anti nuclear ribonucleoprotein(nRNP) autoantibody WHO Reference Reagent    

W1066    Rheumatoid Arthritis serum. WHO Reference Reagent    

YF    Anti-Yellow Fever Serum, monkey WHO Reference Reagent    

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