Interbioscreen Ltd
InterBioScreen
InterBioScreen公司成立于1998年，俄罗斯著名化学合成产品制造商，世界领先的高通量化合物筛选提供商，目前提供超过550000种化合物可用库存，提供超过485,000种具有功能化杂环药物分子的化合物，化合物库是通过非常严格地选择最有可能成为新药或植物保护剂或兽医制剂的最有趣的一类化合物来生成的；化合物文库的主要标准是药效团的新颖性、丰富性和多样性，以及“类药物分子”的结构；公司化合物库每季度更新一次，化合物的数量以大约5000 – 10000个化合物的速度增加。其中约60000多种天然化合物及其衍生物和类似物。
Synthetic Compounds 合成产品库
合成化合物(SC)汇集了包含超过485000即时发货可用的化合物，部分集成的IBS SC集合由Syntest Ltd.， NELBI Ltd.， ChemEx Inc.， ExiMed Ltd.的最佳集合组成。Interbioscreen已经购买了这些选定的子集合，现在都属于Interbioscreen的资源。IBS的合成文库是围绕功能化杂环类药物分子构建的，其中大多数是不能组合得到的，从一开始，IBS就通过严格选择最有趣的课程来生成它的库。
The Synthetic Compound (SC) collection contains over 485 000 immediately available compounds.
Part of the integrated IBS SC collection is composed of the best of the Syntest Ltd., NELBI Ltd., ChemEx Inc., ExiMed Ltd. collections. Interbioscreen has purchased these selected sub-collections which are now Interbioscreen’s property. The synthetic library of IBS is built around functionalized heterocyclic drug-like molecules. Most of these cannot be obtained combinatorially. From the very start, IBS has been generating its library by making a very strict selection of the most interesting classes of compounds which have potential of becoming new drugs or plant protection agents or preparations for use in veterinary. We were less interested in simple hydrazones, hydrazides, Schiff’s bases or readily decomposing compounds. The major criterion for the inclusion of a compound in the collection has been the novelty, abundance in pharmacophores, diversity and the “drug-like molecule” structure.
The collection continues to grow at a rate of approximately 5 000 – 10 000 compounds quarterly. Every six months we send out to customers lists of new acquisitions or updated STOCK databases.
The Natural Compound (NC) collection 天然产物库
世界上最大的天然产物库之一
The Natural Compound (NC) collection is one of the world’s largest and this fact has been acknowledged by the companies which pursue screening programs in Japan, Europe and the US.
We started to build up the NC collection in 1984, and to-date it has grown to include
over 68 000 compounds. Originally the main contributors of natural compounds & derivatives were research institutes of the former Soviet Union, e.g. institutes for plant chemistry, bioorganic chemistry, botanical institutes, institutes for biochemistry of microorganisms, phytopathology of plants etc. With time, we have expanded our sources of rare and unique natural compounds and over the past decade the collection has considerably grown due to the influx of natural products from Asia, Latin America, some European centers for natural products etc. In percentage terms, the collection can be said to comprise 30 – 35% of strictly natural compounds isolated from plants, microorganisms, marine species etc.; approximately 40% are derivatives of natural compounds, i.e. modified alkaloids, terpenoids, flavonoids etc, and the remaining 25-30% are mimetics (analogs) of the strictly natural compounds, e.g. azosteroids, azocoumarins, conjugated isoindole systems, oxaterpenoids etc.
Of the whole NC library, 60 – 65% are compounds of plant origin; 5-10% were isolated from microorganisms, about 5% from marine species and the rest from other natural sources. All compounds have purity at 92-98%. The structures and stereochemistry are confirmed by various physicochemical analytical methods, including NMR (Brucker 300 – 500 MHz), mass spectroscopy and in some cases X-ray analysis.
The most representative classes include various types of alkaloids (several thousand compounds), terpenoids (several thousand), flavonoids and coumarins (over 3 000 compounds), peptides, glycosides and nucleosides (over 1 000 compounds), phenol compounds (several hundred). The collection is also rich in rare and unusual compounds, such as various classes of phytoalexins, allelopathic agents, specific sex attractants, natural toxins, unusual sesquiterpenoids and other secondary metabolites. Apart from this, we also have a collection of functionalized natural compounds which can be used in Natural Combinatorial Chemistry as natural matrices. Compounds in this collection are available in the amounts from several grams up to several hundred grams. As a rule, we package natural compounds in vials or microplates as 2 mg – 5 mg – 10 mg – 20 mg – 50 mg samples.
Timeframe for delivery:
one week for up to 500 compounds;
two weeks for 1 000 cmpds;
3-4 weeks for upwards of 3 000 compounds and approximately
6 weeks for more than 5 000 compounds.
If hits or leads should be discovered in the course of testing, we are ready to re-supply the active compounds and offer analogs for further tests.
Building Blocks
The Building Blocks (BB) collection currently contains
over 13 000 natural and synthetic in-stock-available building blocks.
The classification of the Building Blocks is indicated in the following fields.
PA Primary Amines
SA Secondary Amines
AL Alcohols
AK Aldehydes & Ketones
CA Carboxylic Acids
ES Esters
AN Anhydrides & Haloanhydrides
PH Phenols
AA Aminoacids & their derivatives
PE Peptides & their derivatives
CH Carbohydrates & their derivatives
NU Nucleotides & Nucleosides
ST Steroids & Terpenoids
HAE Haloid Alkyles & Epoxydes
SH Thiols
OCC Other Chemical Classes or Polyfunctional reagents
HY Hydrazines & Hydrazones
IC Isocyanates
ITC Isothiocyanates
SC Sulfochlorides